What is the best way to take Cialis daily? For treating ED, the Cialis dosage for daily use is 2.5 mg once per day. You do not have to take Cialis at any specific time before sexual activity when it's prescribed in this way. You can take your dose at any time of day. But you should try to take it at the same time every day. What is Cialis Black? Cialis Black is a male enhancement medication that is used to treat men with erectile dysfunction. It is a powerful version of one of the more popular medications that is commonly used to treat this problem.