How to Use Modafinil Tablets Take Modafinil Tablets exactly as prescribed by your doctor. Swallow the tablet with water. It is usually taken in the morning or as directed by your healthcare provider. If prescribed for shift work sleep disorder, follow the timing instructions carefully. Do not increase, decrease, or stop the dose without medical advice. Avoid taking it late in the day unless instructed by your doctor. Follow the full treatment plan provided by your physician.