How to Use Take the dose exactly as prescribed by your doctor — usually 0.1mg 2-3 times daily. Maintain a consistent schedule to prevent blood pressure spikes. Swallow with water, with or without food. Do not stop abruptly — it may cause rebound hypertension. In case of missed dose, take it ASAP unless it’s close to the next dose. Your blood pressure and heart rate should be monitored regularly while using Catapres.