Methadone Tablets Price in Pakistan | Uses, Benefits & Medical Info Methadone Tablets are prescription-only opioid medications used primarily for opioid dependence treatment (opioid substitution therapy) and for the management of severe chronic pain when other pain treatments are ineffective. Methadone works by acting on opioid receptors in the brain to reduce withdrawal symptoms, cravings, and pain without producing the intense euphoria associated with other opioids when used correctly.